When animal activists steal a python from a research lab they release it into the everglades unaware that the python just happens to have been experimented on and happens to grow into a giant python. When ranger Terry O'Hara (Tiffany) becomes aware that the gators are being killed by giant pythons she decides to drop food laced with growth hormone for the gators. Unfortunately her plans back fire when the giant gators and giant pythons start battling on the streets leading to Terry and nature experiment Dr. Nikki Riley (Debbie Gibson) to face off over the survival of the animals.
Giant snakes, giant gators and a giant mess but heck what else would you expect from a movie called "Mega Python vs. Gatoroid". I suppose I should say that in a way "Mega Python vs. Gatoroid" is a success because no one would watch it for anything but 90 minutes of badness which is what you get but it is badness which is not in the least bit entertaining. And that more than anything is depressing because you want it to be entertainingly bad with poor special effects and cheesy dialogue which makes you laugh rather than just groan which sadly is what you will find yourself doing a lot. Oh and it is not just the poor special effects and bad dialogue as there are scenes which whilst supposed to be at different times have obviously been shot one after the other with the actors in the exact same position having not moved.
Of course there is another reason why you might want to watch "Mega Python vs. Gatoroid" as it features 80s pop stars Tiffany & Debbie Gibson. Unfortunately the bringing together of these two pop princesses does little to make it entertaining although we do get a catfight which makes up for a lot of rubbish. In the end it is the supporting performances which end up more entertaining with the likes of A Martinez and Kathryn Joosten lending their faces to this dire movie.
What this all boils down to is that "Mega Python vs. Gatoroid" is not only an expectedly bad movie but one which is so bad that it isn't even funny. And sadly even the potential entertainment of having Tiffany and Debbie Gibson in the same movie ends up as terrible as the movie itself.